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International NeuroHIV Cure Consortium

The mission of the International NeuroHIV Cure Consortium (INHCC) is to provide cutting-edge investigation and expertise globally in central nervous system (CNS) aspects of HIV infection relevant to pathogenesis, treatment, and HIV remission, or ‘cure.’  Beginning with our first project in 2009 to evaluate the neurological implications of acute HIV infection, the research group has grown to now encompass investigation into a broad array of early infection and cure strategy work. The consortium was established in 2014 to facilitate scientific exchange among investigators in a diverse array of fields and to leverage all aspects of the research portfolio through multidisciplinary studies during acute HIV infection and the setting of antiretroviral therapy and studies focused on a cure for HIV.​

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Our Research

The INHCC conducts collaborative research across multiple global sites, with a particular focus in Thailand and Africa, to better understand HIV within the central nervous system (CNS). By bringing together multidisciplinary expertise, we aim to address one of the most complex barriers to curing HIV: viral persistence in the CNS.

Latest Publications

Phillip Chan, et al. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. J Infect Dis. 2025

This study evaluates the degree of neuroaxonal injury during acute HIV infection (AHI) in neuroasymptomatic individuals and the neuroprotective effect of antiretroviral therapy (ART) initiated during AHI, by measuring neurofilament light, glial fibrillary acidic protein, and soluble triggering receptor expressed on myeloid cells 2 in cerebrospinal fluid samples collected during pre-ART AHI and at post-ART visits up to 5 years.

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INHCC work is sponsored by NIH, NIMH, NINDS, NIAID, the Henry Jackson Foundation (HJF) and the Walter Reed Army Institute of Research (WRAIR).

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