SEARCH Publications

CNS Injury

• Absence of cerebrospinal fluid signs of neuronal injury before and after immediate antiretroviral therapy in acute HIV infection. J Infect Dis. 2015.

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Imaging

• Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection. PLoS ONE 2012.

Immunology

• Normalization of Soluble CD163 after Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018.
• Acute Retroviral Syndrome is Associated with High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Clin Infect Dis. 2017. 
• High number of activated CD8+ T cells targeting HIV antigens are present in cerebrospinal fluid in acute HIV Infection. J Acquir Immune Defic Syndr. 2017.
• Immediate initiation of antiretroviral therapy is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS. 2017
• Virologic and Immunologic Characteristics of HIV-infected individuals at the Earliest Stage of Infection. J Virus Erad. 2016.

Neuro/Cognitive

• Depression and anxiety are common in acute HIV infection and associate with plasma immune activation. AIDS and Behavior. 2017.
• Cognitive Impairment and Persistent CNS Injury in Treated HIV. Curr HIV/AIDS Rep. 2016.
• Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016.
• Neuropsychological Testing Performance During Acute HIV Before and After Antiretroviral Therapy. JAIDS 2015.
• Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV. PLoS One. 2015.

Research Methods

• Safety of lumbar puncture procedure in an international research setting during acute HIV infection. J Virus Erad. 2018. 

Reservoirs/Cure

• Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.  J Virology. 2018
• CNS reservoirs for HIV: implications for eradication. J Virus Erad. 2015.
• HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy. AIDS. 2014.
• HIV DNA reservoirs increase risk for cognitive disorders in cART- naive patients. PLoS One. 2013.

Virology

• Distribution of HIV RNA in CSF and Blood is linked to CD4/CD8 Ratio During Acute HIV. J Infect Dis. 2018.
• CNS viral invasion and inflammation during acute HIV. J Infect Dis 2012.​​

Other NeuroHIV References

• Immune activation in the central nervous system throughout the course of HIV infection. Curr Opin HIV AIDS. 2016.
• Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection. PLoS Pathog. 2015.
• Deep sequencing of HIV-1 variants from paired plasma and cerebrospinal fluid during primary HIV infection. J Virus Erad. 2015.
• Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection. J Neuroinflammation. 2014.
• An example of genetically distinct HIV type 1 variants in cerebrospinal fluid and plasma during suppressive therapy. J Infect Dis. 2013.
• Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary infection. J Infect Dis. 2013.
• Central nervous system invasion and inflammation during acute HIV infection. J Infect Dis. 2012.
• Central nervous system immune activation characterizes primary HIV infection even in participants with minimal cerebrospinal fluid burden. J Infect Dis. 2011.
• HIV replication in the central nervous system occurs in two distinct cell types. PLoS Pathog. 2011.

• Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection. J Virol. 2009.
• Immediate initiation of antiretroviral therapy is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS 2017.​
• Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2016.
• Putamen volume and its clinical and neurological correlates in primary HIV infection. AIDS. 2016.
• Sex differences in soluble markers vary before and after the initiation of antiretroviral therapy in chronically HIV infected individuals. AIDS. 2016.
• Neuropsychological Testing Performance During Acute HIV Before and After Antiretroviral Therapy. JAIDS 2015.
• Association between brain volumes and HAND in cART-naïve HIV+ individuals from Thailand. J Neurovirl. 2015.
• Cerebral white matter integrity during primary HIV infection. AIDS. 2015.
• Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais. J Neuroimmunol. 2015.
• Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2015.
• Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection. Neurology. 2014.
• Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter. Neurology. 2013.
• HIV DNA in monocytes as a mechanisms to dementia and other HIV complications. J Leukoc Biol. 2010.

SEARCH Abstracts and Presentations ​

2018

• Determinants of immunological non-response after initiation of ART in Acute HIV. Ryan Handoko (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
  
• Intact structural and functional brain imaging in acute HIV. Vishal Samboju (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
  
• Cerebral Glutathione metabolism in acute HIV infection and response to ART. Dr. Sailasuta Napapon at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
  
• CSF and blood HIV RNA relationship in acute HIV is linked to CD4/CD8 ratio. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 
  
• Longitudinal cognitive outcomes after treatment in acute HIV infection. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
  
• Neurologic stability with brief analytic treatment interruption after early ART. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 

2017

• Heightened systemic and CNS immune activation in acute HIV infection with syphilis.  Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).

• MRS measures associate with impaired neuropsychological performance in acute HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• CSF S100B and CX3CR1 monocytes in acute HIV infection predict putamen atrophy.  Dr. Kalpana J. Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Plasma soluble CD163 is suppressed upon early ART initiation in acute HIV infection.  Dr. Michelle L. D'Antoni at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• Deep sequencing reveals rare CNS compartmentalization in acute HIV-1 infection. Dr. Rujipas Sirijatuphat at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• CNS monitoring of cart interruption in individuals treated during fiebig I acute HIV. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Early macrophage-independent inflammation and SHIV-RNA in CNS in a rhesus SHIV model. Dr. Sandhya Vasan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.

2016

• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following treatment interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 2016 Towards an HIV Cure Symposium, July 16 & 17, 2016, Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the International AIDS Society Towards a Cure Symposium 2016.
• Assessing HIV Transmission Networks in a Thai Cohort with Acute HIV Infection. Dr. Eugene Kroon at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Brain Volumetric Changes After Two Years of ART Initiated During Acute HIV Infection. Dr. Kalpana Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Dual Role of Activated and HIV-specific CD8 T cells in CSF during Acute HIV Infection. Dr. Lydie Trautmann at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• HIV DNA set point remains elevated in untreated vs. treated acutely infected Thais. Dr. Jintanat Ananworanich at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Neurologic Signs and Symptoms Frequently Manifest in Acute HIV Infection. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Peripheral Immune Activation Modulates HIV RNA Entry to CSF in Early Acute Infection. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Psychiatric Symptoms are Common in Acute HIV and Correlate with Disease Biomarkers. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Reduced Peripheral α4β7+ CD4+ T Cells Correlate with Mucosal CD4+ T Cell Loss in AHI. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Virologic Failure is Uncommon after Treatment is Initiated during Acute HIV Infection. Dr. Trevor A. Crowell at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).

2015

• Acute HIV CSF/Plasma RNA Ratios Are Variable and Greater than in Chronic HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• Astrocyte and Microglial Activation in Acute and Chronic HIV pre- and post-CART. Dr. Michael Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• CD14+ PBMC Secrete Cytokines Linked to HIV-Associated Neurocognitive Disorders. Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).

• Effects of Treatment During Acute HIV Infection on HIV Persistence. Dr. Jintanat Ananworanich at Keystone Symposia: Mechanisms of HIV Persistence: Implications for a Cure (E1) 2015.

2014

• Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation, and High Viral and Proviral Burden in Systemic and Tissue Compartments. Dr. Trevor Crowell at IDWeek 2014.
• CNS Outcomes of cART vs. cART plus Maraviroc and Raltegravir Intensification During Acute HIV.  Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Antiretroviral Therapy Appears to Normalize Intrathecal Markers of Immune Activation. Dr. Julia Peterson at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Monocyte Inflammation Among Treatment-Naive Acute HIV-Infected Thai Subjects.  Dr. Lishomwa C. Ndhlovu at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Immediate Antiretroviral Therapy Mitigates the Development of Neuronal Injury in Acute HIV.  Dr. Michael J. Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• NeuroHIV in 2014: Beyond Dementia. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2014). Plenary talk. [MP3]
• HIV-Associated Neurocognitive Disease: Mechanisms and Treatment Approaches.  Dr. Serena Spudich at IDWeek 2014.

2013

• CD14+ HIV DNA predicts HIV-associated neurocognitive impairment and regional brain atrophy in treatment-naive subjects.  Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013). 
• Early ART intervention restricts the seeding of the HIV reservoir in long-lived central memory CD4 T cells.  Dr. Jintanat Ananworanich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Gender-specific innate responses vary before and after the initiation of ART in individuals with chronic HIV infection in Thailand.  Dr. Bonnie Slike at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Neuropsychological Performance in Acute HIV: Determinants of Baseline Performance and Effects of Immediate Antiretroviral Therapy.  Dr. Idil Kore at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Trails A test improves performance characteristics of the international HIV dementia scale to identify symptomatic HIV-associated neurocognitive disorder.  Dr. Thep Chalermchai at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

• Very Early Viral Infection of the Central Nervous System without Evidence of Compartmentalization During Acute HIV-1 Infection.  Dr. Serena Spudich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

2012

• Acute HIV infection in a Thai cohort: A longitudinal proton MRS study.  Dr.  Napapon Sailasuta at ISMRM 20th Annual Meeting & Exhibition 2012.
• Brain tCho/Cr is Elevated in Acute HIV within the First Month of Infection: 'brain inflammation in acute infection/immediate HAART may normalize or improve inflammation or perhaps prevent damage'.  Dr. Napapon Sailasuta at at the Conference on Retroviruses and Opportunistic Infections (CROI 2012).

2011

• HIV Brain Viral and Inflammatory Signature During Acute Infection. Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2011).
• HIV-1 specific T cell immune responses in HIV-infected Thai individuals with neurological dysfunction.  Dr. Alexandra Schuetz at the 2nd PMK & AFRIMS Joint Symposium: Research Highlights on Infectious Diseases and Military Medicine 2011.