INHCC Publications via PubMed Here

INHCC Abstracts and Presentations ​

2022

• Immunological, Cognitive and Psychiatric Outcomes after Initiating EFV- and DTG-based Antiretroviral Therapy during Acute HIV Infection, Phillip Chan et al, Clinical Infectious Diseases
• HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies, Phillip Chan, Serena Spudich, Current HIV/AIDS Report
• Compartmentalized clonal expansions of CD8+ T cells in CSF during acute HIV infection, Julie Mitchell et al, Conference on Retroviruses and Opportunistic Infections, 2022
• Multi-compartment fresh single-cell studies in an international HIV research setting, Michael J Corley et al, Conference on Retroviruses and Opportunistic Infections 2022
• Correlations of undetectable HIV DNA 96 weeks after ART initiation during acute HIV, Gunn Pungpapong et al, Conference on Retroviruses and Opportunistic Infections 2022
• Brain volumetrics differ by Fiebig Stage in acute infection, Jacob Bolzenius et al, Conference on Retroviruses and Opportunistic Infections 2022
  

2021

• Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection, Sharma etal, PLoS Pathogens 2021
• Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART Corley etal, PLOS Pathogens 2021
• Investigating Vascular Diseases in People Living With HIV By Nuclear Imaging Dr Phillip Chan & Dr Serena Spudich, Journal of Nuclear Cardiology 2021
• Cognitive trajectories after treatment in acute HIV infection, Phillip Chan etal, AIDS May 1, 2021
• How to Generate Good Killers By Initiating Art (Not Too) Early? Dr Lydie Trautmann, OHSU-VGTI Conference on Retroviruses and Opportunistic Infections (CROI 2021 Virtual)
• Myeloid CN HIV Reservoirs...The Debate Continues Dr Lishomwa Ndhlovu, Weill Cornell, CROI 2021 Virtual
• 3T Brain MRS reveals distinct metabolite patterns of ART initiation during acute HIV, Dr Napapon Sailasuta, Conference on Retroviruses and Opportunistic Infections CROI 2021 Virtual)
• HMMCgag assay detects high levels of residual viremia on ART started during acute HIV infection. Dr Donn Colby, CROI 2021 Virtual
• Predictive models of variable clinical response to antiretroviral therapy among individuals who initiated treatment during acute infection. Dr Robert Paul, U of Missouri-St Louis, CROI 2021 Virtual
• Baseline Monocyte HIV RNA predicts blunted cognitive trajectories in acute infection, Dr Ivo SahBandar, Weill Cornell, CROI 2021 Virtual
• Stable improvement of depression 6 years After ART initiation during acute HIV. Dr Phillip Chan, IHRI SEARCH, CROI 2021 Virtual
• Blips Incidence on Dolutegravir or Efavirenz Based ART during Acute HIV Infection. Bharat Nandakumar, U of Milan, CROI 2021 Virtual

2020

• Clinical and laboratory outcomes 24 weeks after starting DTG vs EFV in acute HIV. Dr Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2020).
• Plasma and cerebrospinal fluid soluble CD30 in acute and early-treated HIV infection. Dr Michael Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2020).
• A randomized trial of adjunctive Telmisartan to reduce CNS inflammation in acute HIV. Dr Michael Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2020).
• Infiltration of bNAb VRC01 into the cerebrospinal fluid in humans in the RV397 study. Dr Prabhakaran at the Conference on Retroviruses and Opportunistic Infections (CROI 2020).
• Neuroinflammation and reactive gliosis during long-term ART initiated in acute HIV. Dr Sailasuta at the Conference on Retroviruses and Opportunistic Infections (CROI 2020). 
• Evolution of immune activation biomarkers in CSF in Fiebig I-V acute HIV infection. Dr J Weiss at the Conference on Retroviruses and Opportunistic Infections, (CROI 2020).
• Is reluctance to restart ART a risk at ATI trials? Dr G Henderson at 23rd International AIDS Conference, 2020
• What does 'HIV cure" mean to acutely diagnosed Thai individuals invited to remission trials with ATI, Holly Peay at 23rd International AIDS Conference, 2020
• Perceived health and stigma among a population of individuals diagnosed with acute HIV. Holly Peay at 23rd International AIDS Conference, 2020
• Willingness to participate in short and extended ATI during HIV remission trials. Dr G Henderson at 23rd International AIDS Conference, 2020

2019

• CSF escape not detected in acute HIV infection. Ryan Handoko (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy. Dr. Philip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Resting-state connectivity associates with depression symptoms in acute HIV. Dr. Carissa L. Philippi at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• CSF HIV-specific T cells persist during ART and associate with lower CNS inflammation. Dr. Caroline Subra Poster at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Early ART in acute HIV limits detrimental CX3CR1 monocytes linked to CNS dysfunction. Dr. Michelle L. D’Antoni at the Conference on Retroviruses and Opportunistic Infections (CROI 2019). 
• Capturing DNA methylation changes in monocytes when initiating ART in Acute HIV. Dr. Michael J. Corley at the Conference on Retroviruses and Opportunistic Infections, March 4-7, 2019, Seattle, Washington (CROI 2019).
• Effect of Telmisartan given at ART initiation in AHI on immune cells in lymph nodes. Dr. Supranee Buranapraditkun at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).

2018

• Determinants of immunological non-response after initiation of ART in Acute HIV. Ryan Handoko (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
• Intact structural and functional brain imaging in acute HIV. Vishal Samboju (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
• Cerebral Glutathione metabolism in acute HIV infection and response to ART. Dr. Sailasuta Napapon at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
• CSF and blood HIV RNA relationship in acute HIV is linked to CD4/CD8 ratio. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 
• Longitudinal cognitive outcomes after treatment in acute HIV infection. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
• Neurologic stability with brief analytic treatment interruption after early ART. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 

2017

• Heightened systemic and CNS immune activation in acute HIV infection with syphilis.  Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).

• MRS measures associate with impaired neuropsychological performance in acute HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• CSF S100B and CX3CR1 monocytes in acute HIV infection predict putamen atrophy.  Dr. Kalpana J. Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Plasma soluble CD163 is suppressed upon early ART initiation in acute HIV infection.  Dr. Michelle L. D'Antoni at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• Deep sequencing reveals rare CNS compartmentalization in acute HIV-1 infection. Dr. Rujipas Sirijatuphat at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• CNS monitoring of cart interruption in individuals treated during fiebig I acute HIV. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Early macrophage-independent inflammation and SHIV-RNA in CNS in a rhesus SHIV model. Dr. Sandhya Vasan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.

2016

• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following treatment interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 2016 Towards an HIV Cure Symposium, July 16 & 17, 2016, Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the International AIDS Society Towards a Cure Symposium 2016.
• Assessing HIV Transmission Networks in a Thai Cohort with Acute HIV Infection. Dr. Eugene Kroon at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Brain Volumetric Changes After Two Years of ART Initiated During Acute HIV Infection. Dr. Kalpana Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Dual Role of Activated and HIV-specific CD8 T cells in CSF during Acute HIV Infection. Dr. Lydie Trautmann at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• HIV DNA set point remains elevated in untreated vs. treated acutely infected Thais. Dr. Jintanat Ananworanich at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Neurologic Signs and Symptoms Frequently Manifest in Acute HIV Infection. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Peripheral Immune Activation Modulates HIV RNA Entry to CSF in Early Acute Infection. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Psychiatric Symptoms are Common in Acute HIV and Correlate with Disease Biomarkers. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Reduced Peripheral α4β7+ CD4+ T Cells Correlate with Mucosal CD4+ T Cell Loss in AHI. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Virologic Failure is Uncommon after Treatment is Initiated during Acute HIV Infection. Dr. Trevor A. Crowell at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).

2015

• Acute HIV CSF/Plasma RNA Ratios Are Variable and Greater than in Chronic HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• Astrocyte and Microglial Activation in Acute and Chronic HIV pre- and post-CART. Dr. Michael Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• CD14+ PBMC Secrete Cytokines Linked to HIV-Associated Neurocognitive Disorders. Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).

• Effects of Treatment During Acute HIV Infection on HIV Persistence. Dr. Jintanat Ananworanich at Keystone Symposia: Mechanisms of HIV Persistence: Implications for a Cure (E1) 2015.

2014

• Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation, and High Viral and Proviral Burden in Systemic and Tissue Compartments. Dr. Trevor Crowell at IDWeek 2014.
• CNS Outcomes of cART vs. cART plus Maraviroc and Raltegravir Intensification During Acute HIV.  Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Antiretroviral Therapy Appears to Normalize Intrathecal Markers of Immune Activation. Dr. Julia Peterson at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Monocyte Inflammation Among Treatment-Naive Acute HIV-Infected Thai Subjects.  Dr. Lishomwa C. Ndhlovu at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Immediate Antiretroviral Therapy Mitigates the Development of Neuronal Injury in Acute HIV.  Dr. Michael J. Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• NeuroHIV in 2014: Beyond Dementia. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2014). Plenary talk. [MP3]
• HIV-Associated Neurocognitive Disease: Mechanisms and Treatment Approaches.  Dr. Serena Spudich at IDWeek 2014.

2013

• CD14+ HIV DNA predicts HIV-associated neurocognitive impairment and regional brain atrophy in treatment-naive subjects.  Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013). 
• Early ART intervention restricts the seeding of the HIV reservoir in long-lived central memory CD4 T cells.  Dr. Jintanat Ananworanich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Gender-specific innate responses vary before and after the initiation of ART in individuals with chronic HIV infection in Thailand.  Dr. Bonnie Slike at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Neuropsychological Performance in Acute HIV: Determinants of Baseline Performance and Effects of Immediate Antiretroviral Therapy.  Dr. Idil Kore at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Trails A test improves performance characteristics of the international HIV dementia scale to identify symptomatic HIV-associated neurocognitive disorder.  Dr. Thep Chalermchai at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

• Very Early Viral Infection of the Central Nervous System without Evidence of Compartmentalization During Acute HIV-1 Infection.  Dr. Serena Spudich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

2012

• Acute HIV infection in a Thai cohort: A longitudinal proton MRS study.  Dr.  Napapon Sailasuta at ISMRM 20th Annual Meeting & Exhibition 2012.
• Brain tCho/Cr is Elevated in Acute HIV within the First Month of Infection: 'brain inflammation in acute infection/immediate HAART may normalize or improve inflammation or perhaps prevent damage'.  Dr. Napapon Sailasuta at at the Conference on Retroviruses and Opportunistic Infections (CROI 2012).

2011

• HIV Brain Viral and Inflammatory Signature During Acute Infection. Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2011).