INHCC Publications

• ​Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V; SEARCH010/RV254 Study Group. Regional brain volumetric changes despite two years of treatment initiated during acute HIV infection. AIDS. 2019 Nov 12. doi: 10.1097/QAD.0000000000002436. PMID: 31725432. IMAGING
• Chan P, Dumrongpisutikul N, Subra C, Colby D, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich A, Trautmann L, Spudich S. Neurosyphilis during Acute HIV Infection: A CNS Immunologic and Virologic Characterization. J Acquir Immune Defic Syndr. 1 Oct 2019. doi: 10.1097/QAI.0000000000002114. PMID: 31180994.  IMMUNOLOGY
• Tovanabutra S, Sirijatuphat R, Pham P, Bonar L, Harbolick E, Bose M, Song H, Chang D, Oropeza C, O’Sullivan AM, Balinang J, Kroon E, Colby D, Sacdalan C, Hellmuth J, Chan P, Prueksakaew P, Pinyakorn S, Jagodzinski L, Sutthichom D, Pattamaswin S, de Souza M, Gramzinski RA, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J, Valcour V, Kijak G, Sanders-Buell E, Spudich S. Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.  Cells. 15 Aug 2019. doi: 10.3390/cells8080902. PMID: 31443253. VIROLOGY
• O Goh, D Colby, S Pinyakorn, C Sacdalan, E Kroon, P Chan, N Chomchey, R Kanaprach, P Prueksakaew, D Suttichom, R Trichavaroj, S Spudich, M Robb, P Phanuphak, N Phanuphak, J Ananworanich, on behalf of RV254/SEARCH 010 Study Group. Switch to Dolutegravir is well tolerated in Thais with HIV infection.  Journal of the International AIDS Society. 11 Jul 2019. doi: 10.1002/jia2.25324.  PMID: 31294931. ANTIRETROVIRAL EFFECTS
• Patel P, Apornpong T, Puthanakit T, Thongpibul K, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S, Ngampiyaskul C, Luesomboon W, Wongsawat J, Penh Sun L, Chettra L, Saphonn V, Mellins CA, Malee K, Spudich S, Ananworanich J., Kerr S*, Paul R.*. Group Based Trajectory Analysis of Cognitive Outcomes in Children with Perinatal HIV. Pediatr Infect Dis J, in press. NEURO/COGNITIVE
• Chan P, Ananworanich J. Perspective on Potential Impact of HIV CNS Latency on Eradication. AIDS. 13 May 2019. doi: 10.1097/QAD.0000000000002264. PMID: 31090545. RESERVOIRS/CURE
• Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S; SEARCH 010/RV254 and SEARCH013/RV304 Study Groups. Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation. J Infect Dis. 2019 Jan 21. doi: 10.1093/infdis/jiz030. PMID: 30668739. IMMUNOLOGY
• Chintanaphol M, Sacdalan C, Chottanapund S, Pinyakorn S, Buranapraditkun S, Crowell TA, Kroon E, Manasnayakorn S, Chipman JG, Schacker TW, Michael N, Phanuphak N, Spudich SS, Colby DJ, Ananworanich J. Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):244-248. doi: 10.1097/QAI.0000000000001780.PMID: 30212436 RESEARCH METHODS
• Samboju V, Philippi CL, Chan P, Cobigo Y, Fletcher JLK, Robb M, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Paul R, Ananworanich J, Spudich S, Valcour V, for the , SEARCH 010/RV254, RV304 protocol teams. Neuroimage Clin. 2018 Jul 27;20:327-335. doi: 10.1016/j.nicl.2018.07.024. eCollection 2018. PMID:30101063 | PMCID:PMC6082997. IMAGING
• D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC; RV254/SEARCH010; SEARCH011 and RV304/SEARCH013 study groups. Normalization of Soluble CD163 after Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018 Jun 2. doi: 10.1093/infdis/jiy337. PMID:29868826. IMMUNOLOGY
• Chan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S; RV254/SEARCH 010 Study Team. Distribution of HIV RNA in CSF and Blood is linked to CD4/CD8 Ratio During Acute HIV. J Infect Dis. 2018 May 7. doi: 10.1093/infdis/jiy260. PMID:29741638. VIROLOGY
• Hsu D, Sunyakumthorn P, Wegner M,  Schuetz A, Silsorn D, Estes J, Deleage C, Tomusange K, Lakhashe S, Ruprecht R, Lombardini E, -Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb M, Ndhlovu L, Ananworanich L, Valcour V, O’Connell R, Spudich S,  Michael N, Vasan S. Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.  J Virology, 2018 Mar 21. RESERVOIRS/CURE
• Chan P, Hellmuth J, Colby D, Kroon E, Sacdalan C, Fletcher J, Patel P, Pinyakorn S, Valcour V, Ananworanich J, Spudich S. Safety of lumbar puncture procedure in an international research setting during acute HIV infection. J Virus Erad. 2018 Jan 1;4(1):16-20. PubMed [citation] PMID: 29568548 RESEARCH METHODS
• Crowell TA, Colby DJ, Pinyakorn S, Fletcher JLK, Kroon E, Schuetz A, Krebs SJ, Slike BM, Leyre L, Chomont N, Jagodzinski LL, Sereti I, Utay NS, Dewar R, Rerknimitr R, Chomchey N, Trichavaroj R, Valcour VG, Spudich S, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV254/SEARCH010 Study Group. Acute Retroviral Syndrome is Associated with High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Clin Infect Dis. 2017 Dec 7. doi: 10.1093/cid/cix1063. PMID: 29228130. IMMUNOLOGY
• Hellmuth J, Colby D, Valcour V, Suttichom D, Spudich S, Ananworanich J, Prueksakaew P, Sailasuta N, Allen IE, Slike B, Ochi D, Paul R. Depression and anxiety are common in acute HIV infection and associate with plasma immune activation. AIDS and Behavior. 2017 Nov;21(11):3238-3246. NEURO/COGNITIVE
• Kessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Nichols C, Josey BJ, Slike B, Krebs SJ, Sailsuta N, Lerdlum S, Jagodinski L, Tipsuk S, Suttichom D, Rattanamansee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb ML, Michael NL, Ananworanich J, Trautmann L.  High number of activated CD8+ T cells targeting HIV antigens are present in cerebrospinal fluid in acute HIV Infection. J Acquir Immune Defic Syndr. 2017 May 1;75(1):108-117. IMMUNOLOGY
• Michael J. Peluso, Victor Valcour, Nittaya Phanuphak, Jintanat Ananworanich, James LK Fletcher, Thep Chalermchai, Shelly J. Krebs, Merlin L. Robb, Joanna Hellmuth, Magnus Gisslén, Henrik Zetterberg, Serena Spudich, on behalf of the RV254/SEARCH 010, RV304/SEARCH 013, and SEARCH 011 Study Teams. Immediate initiation of antiretroviral therapy is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS. 2017 Jan 14;31(2):247-252. IMMUNOLOGY
• Chan P, Hellmuth J, Spudich S, Valcour V.  Cognitive Impairment and Persistent CNS Injury in Treated HIV.  Curr HIV/AIDS Reports, 2016 May 17. NEURO/COGNITIVE
• Joanna Hellmuth, James LK Fletcher, Victor Valcour, Eugène Kroon, Jintanat Ananworanich, Jintana Intasan, Sukalaya Lerdlum, Jared Narvid, Mantana Pothisri, Isabel Allen, Shelly J. Krebs, Bonnie Slike, Peeriya Prueksakaew, Linda Jagodzinski, Suwanna Puttamaswin, Nittaya Phanuphak, Serena Spudich, on behalf of the SEARCH 010/RV254 Study Group Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016 Jul 12;87(2):148-54. NEURO/COGNITIVE
• Jintanat Ananworanich, Carlo P. Sacdalan , Suteeraporn Pinyakorn, Nicolas Chomont, Mark deSouza, Tassanee Luekasemsuk, Alexandra Schuetz, Shelly J. Krebs, Robin Dewar, Linda Jagodzinski, Sasiwimol Ubolyam, Rapee Trichavaroj, Sodsai Tovanabutra, Serena Spudich, Victor Valcour, Irini Sereti, Nelson Michael, Merlin Robb, Praphan Phanuphak, Jerome H. Kim, Nittaya Phanuphak on behalf of the RV254/SEARCH010 Study Group. Virologic and Immunologic Characteristics of HIV-infected individuals at the Earliest Stage of Infection. J Virus Erad. 2016; 2:43-48. IMMUNOLOGY
• Idil Kore, Jintanat Ananworanich, Victor Valcour, James LK Fletcher, Duanghathai Suttichom, Peeriya Mangu, Thep Chalermchai, Linda Jagodzinski, Jerome Kim, Serena Spudich, on behalf of the RV254/SEARCH 010 Study Group. Neuropsychological Testing Performance During Acute HIV Before and After Antiretroviral Therapy. JAIDS 2015 NEURO/COGNITIVE
• Hellmuth J, Valcour V and Spudich S.  CNS Reservoirs for HIV: Implications for Eradication.  Journal of Viral Eradication, 2015 Apr;1(2):67-71.  RESERVOIRS/CURE
• Peluso MJ, Valcour V, Ananworanich J, Sithinamsuwan P, Chalermchai T, Fletcher JLK, Lertlum S, Chomchey N, Slike N, Sailasuta N, Gisslen M, Zetterberg H, Spudich S on behalf of the RV254/SEARCH 010 and SEARCH 011 Study Teams. Absence of cerebrospinal fluid signs of neuronal injury before and after immediate antiretroviral therapy in acute HIV infection. JID 2015 CNS INJURY
• Valcour VG, Spudich SS, Sailasuta N, Phanuphak N, Lerdlum S, Fletcher JLK, Kroon EDMB, Jagodzinski LL, Allen IE, Prueksakaew P, Slike BM, Hellmuth JM, Kim JH, Ananworanich J. Neurologic response to cART vs. cART plus integrase inhibitor and CCR5 antagonist initiated during acute HIV. PLoS One. 2015 Nov 10;10(11):e0142600 NEURO/COGNITIVE
• Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D, Suwanwela NC, Jagodzinski L, Michael N, Spudich S, van Griensven F, de Souza M,  Kim J, Ananworanich J on behalf of the RV254/SEARCH 010 Study Group. CNS viral invasion and inflammation during acute HIV. J Infect Dis 2012. Jul 15;206(2):275-82. doi: 10.1093/infdis/jis326. Epub 2012 May 2. PubMed [citation] PMID: 22551810, PMCID: PMC3490695 VIROLOGY
• Sailasuta N, Ross W, Ananworanich J, Chalermchai T, DeGruttola V, Lerdlum S, Pothisri M, Busovaca E, Ratto-Kim S, Jagodzinski L, Spudich S, Michael N, Kim JH, Valcour V for the RV254/SEARCH 010 protocol teams. Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection. PLoS ONE 2012 IMAGING

INHCC Abstracts and Presentations ​

2019

• CSF escape not detected in acute HIV infection. Ryan Handoko (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy. Dr. Philip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Resting-state connectivity associates with depression symptoms in acute HIV. Dr. Carissa L. Philippi at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• CSF HIV-specific T cells persist during ART and associate with lower CNS inflammation. Dr. Caroline Subra Poster at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).
• Early ART in acute HIV limits detrimental CX3CR1 monocytes linked to CNS dysfunction. Dr. Michelle L. D’Antoni at the Conference on Retroviruses and Opportunistic Infections (CROI 2019). 
• Capturing DNA methylation changes in monocytes when initiating ART in Acute HIV. Dr. Michael J. Corley at the Conference on Retroviruses and Opportunistic Infections, March 4-7, 2019, Seattle, Washington (CROI 2019).
• Effect of Telmisartan given at ART initiation in AHI on immune cells in lymph nodes. Dr. Supranee Buranapraditkun at the Conference on Retroviruses and Opportunistic Infections (CROI 2019).

2018

• Determinants of immunological non-response after initiation of ART in Acute HIV. Ryan Handoko (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
• Intact structural and functional brain imaging in acute HIV. Vishal Samboju (MD candidate) at the Conference on Retroviruses and Opportunistic Infections (CROI 2018).
• Cerebral Glutathione metabolism in acute HIV infection and response to ART. Dr. Sailasuta Napapon at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
• CSF and blood HIV RNA relationship in acute HIV is linked to CD4/CD8 ratio. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 
• Longitudinal cognitive outcomes after treatment in acute HIV infection. Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). Oral presentation.
• Neurologic stability with brief analytic treatment interruption after early ART. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2018). 

2017

• Heightened systemic and CNS immune activation in acute HIV infection with syphilis.  Dr. Phillip Chan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).

• MRS measures associate with impaired neuropsychological performance in acute HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• CSF S100B and CX3CR1 monocytes in acute HIV infection predict putamen atrophy.  Dr. Kalpana J. Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Plasma soluble CD163 is suppressed upon early ART initiation in acute HIV infection.  Dr. Michelle L. D'Antoni at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• Deep sequencing reveals rare CNS compartmentalization in acute HIV-1 infection. Dr. Rujipas Sirijatuphat at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.
• CNS monitoring of cart interruption in individuals treated during fiebig I acute HIV. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).
• Early macrophage-independent inflammation and SHIV-RNA in CNS in a rhesus SHIV model. Dr. Sandhya Vasan at the Conference on Retroviruses and Opportunistic Infections (CROI 2017). Oral presentation.

2016

• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following treatment interruption in individuals treated during acute HIV infection. Dr. Jintanat Ananworanich at the 2016 Towards an HIV Cure Symposium, July 16 & 17, 2016, Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the 21st International AIDS Conference (AIDS 2016), Durban, South Africa.
• Central nervous system impact of vorinostat, hydroxychloroquine and maraviroc combination therapy followed by treatment interruption in individuals treated during acute HIV infection. Dr. Eugene Kroon at the International AIDS Society Towards a Cure Symposium 2016.
• Assessing HIV Transmission Networks in a Thai Cohort with Acute HIV Infection. Dr. Eugene Kroon at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Brain Volumetric Changes After Two Years of ART Initiated During Acute HIV Infection. Dr. Kalpana Kallianpur at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Dual Role of Activated and HIV-specific CD8 T cells in CSF during Acute HIV Infection. Dr. Lydie Trautmann at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• HIV DNA set point remains elevated in untreated vs. treated acutely infected Thais. Dr. Jintanat Ananworanich at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Neurologic Signs and Symptoms Frequently Manifest in Acute HIV Infection. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Peripheral Immune Activation Modulates HIV RNA Entry to CSF in Early Acute Infection. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Psychiatric Symptoms are Common in Acute HIV and Correlate with Disease Biomarkers. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Reduced Peripheral α4β7+ CD4+ T Cells Correlate with Mucosal CD4+ T Cell Loss in AHI. Dr. Alexandra Schuetz at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).
• Virologic Failure is Uncommon after Treatment is Initiated during Acute HIV Infection. Dr. Trevor A. Crowell at the Conference on Retroviruses and Opportunistic Infections (CROI 2016).

2015

• Acute HIV CSF/Plasma RNA Ratios Are Variable and Greater than in Chronic HIV. Dr. Joanna Hellmuth at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• Astrocyte and Microglial Activation in Acute and Chronic HIV pre- and post-CART. Dr. Michael Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).
• CD14+ PBMC Secrete Cytokines Linked to HIV-Associated Neurocognitive Disorders. Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2015).

• Effects of Treatment During Acute HIV Infection on HIV Persistence. Dr. Jintanat Ananworanich at Keystone Symposia: Mechanisms of HIV Persistence: Implications for a Cure (E1) 2015.

2014

• Acute Retroviral Syndrome is Associated with Gut Mucosal CD4 Depletion, Inflammation, and High Viral and Proviral Burden in Systemic and Tissue Compartments. Dr. Trevor Crowell at IDWeek 2014.
• CNS Outcomes of cART vs. cART plus Maraviroc and Raltegravir Intensification During Acute HIV.  Dr. Victor Valcour at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Antiretroviral Therapy Appears to Normalize Intrathecal Markers of Immune Activation. Dr. Julia Peterson at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Early Monocyte Inflammation Among Treatment-Naive Acute HIV-Infected Thai Subjects.  Dr. Lishomwa C. Ndhlovu at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• Immediate Antiretroviral Therapy Mitigates the Development of Neuronal Injury in Acute HIV.  Dr. Michael J. Peluso at the Conference on Retroviruses and Opportunistic Infections (CROI 2014).
• NeuroHIV in 2014: Beyond Dementia. Dr. Serena Spudich at the Conference on Retroviruses and Opportunistic Infections (CROI 2014). Plenary talk. [MP3]
• HIV-Associated Neurocognitive Disease: Mechanisms and Treatment Approaches.  Dr. Serena Spudich at IDWeek 2014.

2013

• CD14+ HIV DNA predicts HIV-associated neurocognitive impairment and regional brain atrophy in treatment-naive subjects.  Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013). 
• Early ART intervention restricts the seeding of the HIV reservoir in long-lived central memory CD4 T cells.  Dr. Jintanat Ananworanich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Gender-specific innate responses vary before and after the initiation of ART in individuals with chronic HIV infection in Thailand.  Dr. Bonnie Slike at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Neuropsychological Performance in Acute HIV: Determinants of Baseline Performance and Effects of Immediate Antiretroviral Therapy.  Dr. Idil Kore at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).
• Trails A test improves performance characteristics of the international HIV dementia scale to identify symptomatic HIV-associated neurocognitive disorder.  Dr. Thep Chalermchai at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

• Very Early Viral Infection of the Central Nervous System without Evidence of Compartmentalization During Acute HIV-1 Infection.  Dr. Serena Spudich at at the Conference on Retroviruses and Opportunistic Infections (CROI 2013).

2012

• Acute HIV infection in a Thai cohort: A longitudinal proton MRS study.  Dr.  Napapon Sailasuta at ISMRM 20th Annual Meeting & Exhibition 2012.
• Brain tCho/Cr is Elevated in Acute HIV within the First Month of Infection: 'brain inflammation in acute infection/immediate HAART may normalize or improve inflammation or perhaps prevent damage'.  Dr. Napapon Sailasuta at at the Conference on Retroviruses and Opportunistic Infections (CROI 2012).

2011

• HIV Brain Viral and Inflammatory Signature During Acute Infection. Dr. Victor Valcour at at the Conference on Retroviruses and Opportunistic Infections (CROI 2011).